COVID 19 Vaccine Deep Dive: Safety, Immunity, RNA Production, (Pfizer Vaccine / Moderna Vaccine)

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  • 16/12/2020 को प्रकाशित
  • Professor Shane Crotty, PhD joins MedCram to answer a series of COVID vaccine questions including what are the chances of long-term side effects? How safe is RNA vaccine (i.e. Pfizer / BioNTech and Moderna Vaccines) technology? How long does mRNA from a vaccine stay in our cells? What else goes in vaccines? How long does immunity last? Why are T-Cells so important? Why does Pfizer's vaccine need to stay SO cold?
    Shane Crotty, PhD is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Professor Crotty also has an academic appointment with the University of California San Diego. He has earned the rare distinction of "World Expert" in vaccine research by Expertscape which place Professor Crotty in the top 0.1% of scholars publishing information on vaccines over the past 10 years. See his full bio here:
    Professor Crotty on Twitter: profshanecrotty
    Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of
    See our new interview with Prof. Crotty on how virus mutations (UK variant and S. African variant) may be impacting COVID-19 transmission and vaccine efficacy.
    Research referenced in this video from Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science:
    New York Times article highlighting Prof. Shane Crotty's research:
    00:00 Introducing Prof. Shane Crotty's Research
    0:35 How long does COVID-19 "immune memory" last?
    0:57 The three primary aspects of immune memory: antibodies, killer T cells, and helper T cells
    2:25 The anatomy (protein makeup) of SARS-CoV-2
    3:02 Why is spike protein the primary target?
    5:17 Could a mutation allow SARS-CoV-2 to infect without spike protein?
    7:02 Utilizing lipid nanoparticles to deliver mRNA and the role of RNA normally
    9:52 What human cells does an RNA vaccine go into?
    10:36 How long does mRNA from a vaccine stay in human cells?
    11:44 What else goes in vaccines besides mRNA and lipid nanoparticles? Any preservatives or adjuvants?
    12:30 Why are adjuvants used in many vaccines?
    14:08 Protein production from mRNA
    15:00 Why utilize the "extra" step of mRNA to code for protein antigens?
    17:28 Are mRNA vaccines the future of vaccine development?
    19:18 Any chance for mRNA to enter our cells' nucleus?
    20:55 The immune response to a coronavirus vaccine
    23:17 Expected symptoms from immune response to a vaccine vs. vaccine side effects
    25:50 Should people who've had COVID-19 get vaccinated?
    27:27 Immunity from COVID vaccine vs. a natural infection
    28:30 Why does the Pfizer vaccine need to be stored so cold?
    29:04 What would you say to a family member who is nervous about a rushed vaccine and RNA technology?
    32:37 What about the possibility of long term side effects from RNA vaccines?
    33:30 What's next for Shane Crotty's research team?
    (This video was recorded on December 16, 2020).
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    Video Produced by Kyle Allred

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टिप्पणियाँ • 0

  • MedCram - Medical Lectures Explained CLEARLY
    MedCram - Medical Lectures Explained CLEARLY  11 महीने पहले +251

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    Clear explanations of over 60 topics at our website

    • TheFeralTaint
      TheFeralTaint 11 महीने पहले +24

      Thanks for this. I would like to hear this guy’s findings on what immune response or genetic markers correlate with increased risk of hospitalization. I want to know what is actually happening here. Comorbidities just aren’t the answer.

  • T J
    T J 2 दिन पहले

    This is so good, I am much better informed now.

  • Youtube please do not censor us
    Youtube please do not censor us 2 दिन पहले +1

    11 months after, we know immunity lasts months

  • herminigildo apuya
    herminigildo apuya 6 दिन पहले

    Please ask our Filipino scientist Dr. Fabunan and Dr. Richard Gomez the answer to eliminates eradicate destroy and kill the COVID 19 and all Delta Variants..

  • jason halil
    jason halil 6 दिन पहले

    Just saline? what about polyethylglycol? suspected culprit in recipients experiencing myocarditis.
    We now know the vaccines have a 3-6mth efficacy hence boosters every 3-6mths indefinitely?

  • Ivan Pokerznik
    Ivan Pokerznik 9 दिन पहले

    @medcram please give an update - situation one year later

  • treemonk
    treemonk 10 दिन पहले

    Many many many of the questions in the comments here are answered by Dr. Crotty in the video. Viewers who haven't studied biology need to watch this or parts of this video more than once if they really want answers. He very skillfully gives answers to the degree that science has generated them and uses analogies of common events/experiences to clarify the explanations. Immune biology is quite complex in its details and some of the commenters questions require knowing some specific details to be clearly answered. Pay attention and re-view the video to allay some of your fears of the unknown and learn about something you know next to nothing about.

  • heyward boyce
    heyward boyce 19 दिन पहले

    Do I need a booster? After I recovered from COVID-19 in January, I got the Moderna vaccine in April. Do I need a booster now or nah?

  • Traian Danciu
    Traian Danciu 22 दिन पहले

    How many hours must we avoid move vaccinated shoulder to avoid capillary spread of vaccine lyposomes in the blood?

  • Traian Danciu
    Traian Danciu 22 दिन पहले

    Can SARS COV2 infection induce,, low temperature agglutinine,, like mycoplasma infection?

  • Edward Spencer
    Edward Spencer 26 दिन पहले +2

    As pfizer stated in its contracts with governments "long term efficacy and side effects are unknown". So the manufacturer said point blank they have no idea what long term side effects are possible. Anyone talking about "mRNA vaccine safety" who doesn't acknowledge this and speculates is spreading misinformation

  • Breakthemould
    Breakthemould महीने पहले

    This is the best and healthiest discussion ever

  • Michael nukeroell
    Michael nukeroell महीने पहले

    Side effects? And the fact you can still get and spread c19 should be on top of the discuss list

  • Fanfreluche Fanfreluche
    Fanfreluche Fanfreluche महीने पहले

    Very interesting and clearly explained for people to understand them new mRNA Pfizer and Moderna vaccines
    and adenovirus J&J vectors vaccines….

  • ling-li tan
    ling-li tan महीने पहले +21

    I would be interested to know if this doctor still feels the same way about mRNA safety in light of the thousands of death and injuries that have sadly occurred in the vaccinated since this video!

  • Steven Channer
    Steven Channer महीने पहले +1

    So basically
    There are always gonna be booster needed to keep the virus in check because this JAB is only designed to attack 1 little part of this biological warfare virus.

  • Mike Bassman
    Mike Bassman महीने पहले

    What a brilliant video presentation, thank you.

  • Breanne Luce
    Breanne Luce महीने पहले +2

    I would love for him to also answer why some people have no side effects from the vaccine, some have minimal and others have terribal side effects. And is there a way to determine what your body response will be before taking the vaccine.

  • djxsquizit
    djxsquizit महीने पहले +1

    I love how everyones a doctor and a scientist on the comments section 😄😄

  • jon Davis
    jon Davis महीने पहले +2

    No long term studies. I’d like to hear his interpretation of recent Israeli data. What does he think of vaxing children when they aren’t statistically at risk?

  • Bill
    Bill महीने पहले +2

    What about long term side effects? YOU DON'T KNOW!! I think that's a practical question.

  • Nicole B
    Nicole B महीने पहले +2

    Is there an updated video? Bc it has been confirmed now that natural immunity lasts longer, immunity from Vaccines is only months at best, and there are side effects which have been downplayed at the end.

  • Nimal Herat-Gunaratne
    Nimal Herat-Gunaratne महीने पहले

    Thank you professor A great presentation and you made explanations for questions so easy Thank you

  • joanne peterson
    joanne peterson महीने पहले

    Is there an update from this professor on boosters?

  • lady bug
    lady bug महीने पहले

    Is mRNA a sRNA?

  • Jai Me
    Jai Me महीने पहले +1

    How does the spike proteins interact with our bodies T Cell CD8 and CD4 in the long run? There is an assumption that it looks good; however, it is not known for sure. We need emperical evidence...but I guess people are still being studied. But are they tracking?

  • Record Rocker Solo
    Record Rocker Solo महीने पहले +2

    So if you don’t know about natural immunity then why not study that?

  • Gerhard van Niekerk
    Gerhard van Niekerk महीने पहले +1

    Excellent explanation. Thanks very much.

  • SDA Dan Cars
    SDA Dan Cars महीने पहले +1

    Interesting 👍

  • Rick Gerson
    Rick Gerson महीने पहले

    Do the Covid-19 vaccinations shorten telomeres?

  • David Goodwin
    David Goodwin महीने पहले +1

    Covid vaccine for dummies, thanks!! Very well explained 👏

  • J H
    J H महीने पहले

    Thankyou Professor - that was very informative :)

  • Bo Masour
    Bo Masour 2 महीने पहले

    Study of immune memory has a long history. I think it's crazy that in just one year of being aware of the corona virus there has been more immune memory research than any other sickness. This really shows how important it was for society to develop a vaccine, and put the corona virus in our rear view.

  • stevehawkins777
    stevehawkins777 2 महीने पहले +1

    Can you then explain in detail the pharmacokinetics and pharmacodynamics of the covid vaccine/spike protein.

  • Aliyah
    Aliyah  2 महीने पहले

    Some of my family members and I got the vaccine. A lot of my family had covid and they recommended getting the vaccine after having Covid. It must be scary to have the virus, I just hope that everyone who has it can heal and recover quickly. I hope that this vaccine and those tests work correctly.

  • Brendan Foster
    Brendan Foster 2 महीने पहले

    Thank you modern medicine. Thank you to smart dedicated people who have studied for years to try and help people live longer lives.
    Thanks to the other people for using Google and Facebook to keep the stupid people, stupid.

  • Person A
    Person A 2 महीने पहले +2

    A lot of very intelligent questions here. All the comments seem to me to be made by people who ask questions. These two doctors, not so much.

  • aci
    aci 2 महीने पहले

    Can autoimmune condition take the Pfizer vaccine without bad sides effect?

  • Hamid Abrar
    Hamid Abrar 2 महीने पहले +2

    Can anemia patients take the Covid-19 vaccine?

  • 4techboy
    4techboy 2 महीने पहले

    You're a really good interviewer. This guy's wicked smart and he's pretty good at articulating these concepts but when he needs a bit of help you were there with just the right words. Respect 😎

  • Alex Luthiger
    Alex Luthiger 2 महीने पहले +3

    Wait and see. 🍷😎

  • Becky D Holistics
    Becky D Holistics 2 महीने पहले +5

    You really don't know how long natural immunity will last but you don't know how long the mnra vaccine is effective. But the recommendation is to get the shot on top of immunity. How many times did he say We don't know?? This video is 9 months old let's see an update to these questions...

  • Antoinette
    Antoinette 2 महीने पहले +4

    I wish you had asked about the side effects

  • Paul Williams
    Paul Williams 2 महीने पहले +1

    Thank you, Doctor for explaining how the vaccine is made , is it safe to take the jab

  • Elissa Bella Joy
    Elissa Bella Joy 2 महीने पहले +1

    Thank you so much for the informative interview 😊

  • Mike E
    Mike E 2 महीने पहले +4

    Great informative interview, however I would like to know if the vaccine has created the new Delta variant ?

  • Chrissy Thompson
    Chrissy Thompson 2 महीने पहले +2

    While the other immune cells work on making the spike protein will they still be able to attack all other viruses that enter the body?

  • V.J. L.
    V.J. L. 2 महीने पहले +3

    I'm hanging in here until the end of the video hoping to hear this guy say, "that's a really bad question."

  • nalejbank
    nalejbank 2 महीने पहले +6

    QUESTION: Has there EVER been a variant of an original virus that emerged STRONGER than the original?
    It seems the common understanding is that all variants are weaker "offspring", not capable of causing higher mortality rates in those who contract a variant, regardless of whether they contracted the original virus. If this is true, then it's an even greater indictment of both the political weaponization of this "not-so-much-pandemic" and the complete lack of efficacy of these jabs and their boosters!
    So, what's the truth about variants?!

    STEVE FOURNIER 2 महीने पहले

    Shane, what Awsome breakdown, for laymen, how vaccine work, Thank You!

  • Kardum Odalv
    Kardum Odalv 2 महीने पहले +2

    Such a great educational video and yet over 4K thumbs down… it tells you something about IQ of most people… you know what guys? If you think vaccines are dangerous because of little side-effects then please consider this: i’ve recovered from Covid last December and still having sense of smell changed + i’ve developed asthma and have weakened lungs. Do you really want to take chances, be sick for weeks and recovering for months while endangering your parens and grandparents? Just be rational and think about it. Peace.

  • Janet McNutt
    Janet McNutt 2 महीने पहले +1

    So what if you already have already had the virus? How are those antibodies different from what the vaccine gives you?

  • Janet McNutt
    Janet McNutt 2 महीने पहले +2

    So if those of us that had Covid-19 have these antibodies and are exposed to this virus over and over again because we have such an out brake over and over again, shouldn't our antibodies be kept up from the reinfection that we shouldn't get Covin-19 again?

  • Nyanda Nyandalous
    Nyanda Nyandalous 2 महीने पहले

    Thank you.

  • T0masi Brudoctor
    T0masi Brudoctor 2 महीने पहले +1

    So if I get no side effects that's not a positive sign for my immunogenic response?

  • Virgen Figueroa
    Virgen Figueroa 2 महीने पहले +1

    Hi I had ask few times the same question. I had a bad case of covid but I bounce back to health a week later and 10 days after I felt like never had covid. I even had fever convulsions. I was born with a heart issue. Was corrected on 2018. I still have some issues taking currently metropolof. Covid started my arrhythmia. I have SVT I get very scared with the vaccine might trigger my arrhythmia. My arrhythmia goes over 315. Once they had to give me 2 shots of something that felt horrible I tought my spirit was leaving my body. Was very hard to get my heart to a normal rhythm. Also at surgery had 2 hemorrhages. The heart is the only thing that scares me. The heart is a muscle that is a major organ and mines was born with issues. Do u guys think is still safe. Especially after covid. I mea cuz of the reaction to after a positive test.

  • Carol Blaney Ph.D.
    Carol Blaney Ph.D. 2 महीने पहले +8

    I would like a video clarifying all the various additives added to each type of vaccine, and of course why? {eg, thimoserol, Quantum dots, graphene, nanoparticles,} since so many of these ... are being claimed to have definitively been added to the many types of vaccines. . Can MedCram clear all this uncertainty up? thank you. also does anyone have links to clarify this? thanks
    for one example some vaccines have graphene as a component. is this a graphene-platinum sheath-core nanobot? for recording the date and type of injection? and thimoserol for a preservative, ubiquitious in all vaccines as far as I am informed.
    and how can a consumer make an informed decision to get a vaccine if the government refuses to disclose which 'brand' of vaccine is being used? this is so for the country i am in, ey.

  • Michael
    Michael 2 महीने पहले

    This was worth rewatching. INclips randomly played it for me and i wasn’t going to keep watching but it was very educational in regards to how the vaccines are made.

  • T
    T 3 महीने पहले

    Good video.

  • Julie Condoyannis
    Julie Condoyannis 3 महीने पहले +7

    What about the accumulation in the ovaries? Long term reproduction problems

  • Brian Pex
    Brian Pex 3 महीने पहले +1

    Such an honest, non political BS interview. Fantastic.

  • Brian Pex
    Brian Pex 3 महीने पहले

    24:15 - fantastic analogy

  • Michelle Casey
    Michelle Casey 3 महीने पहले

    Thank you for taking time to make this video!

  • james kernan
    james kernan 3 महीने पहले

    Wow, that was great.

  • Marc Williams
    Marc Williams 3 महीने पहले +5

    Now imagine the news could put this kind of actual sane information out.

  • Cambria Wellness
    Cambria Wellness 3 महीने पहले +2

    What is the instruction of the gene code, other than to reproduce more spike proteins?

  • LJ Re
    LJ Re 3 महीने पहले +1

    Don’t you wish you could give more than one 👍🏼?, outta be a law.

  • Remaxproject
    Remaxproject 3 महीने पहले +1

    Good vid. You really asked good cut through questions. I have been hesitant in getting the vaccine, this answered a few of my issues.

  • Keyyyyzzzz
    Keyyyyzzzz 3 महीने पहले +1

    Amazing modern technology and excellent questions answered…. How far biochem has come :-)

  • bm phil
    bm phil 3 महीने पहले

    If you need to get it into lung cells looks like an inhaler delivery would be I way off? A Flonase type vaccine delivery?
    Assuming they get the vaccine to the non experimental state.